Warner Bros. bought the film rights to the book in 1999. Production began in 2000, with Columbus being chosen from a short list of directors to create the film. Rowling insisted that the entire cast be British, in keeping with the cultural integrity of the book and the film. Rowling also approved the screenplay, written by Steve Kloves. The film shot primarily at Leavesden Film Studios, as well as historic buildings around the country, and was released in the United Kingdom and the United States in November 2001. Along with mostly positive critical reception, it made in excess of $976 million at the worldwide box office and received three Academy Award nominations. The second, third, fourth, and fifth books have also been adapted into successful films, with the sixth and seventh confirmed.
Harry Potter is a seemingly ordinary eleven-year-old boy, living with his negligent relatives, the Dursleys. On his eleventh birthday, Harry learns from a mysterious stranger, Hagrid, that he is actually a wizard, famous in the wizarding world for surviving an attack by the evil dark Lord Voldemort, when Harry was only a year old. Voldemort killed Harry's parents, but his attack on Harry failed, leaving only a lightning-bolt scar on Harry's forehead. Harry is invited to begin attending Hogwarts School of Witchcraft and Wizardry.
Harry defies his aunt and uncle, and attends Hogwarts where he begins to learn magic and make new friends, as well as enemies, among the Hogwarts students and staff. Voldemort has been near death, and in hiding, since the attack on Harry ten years earlier, but a plot is brewing for the dark lord to regain his power and strength through the acquisition of a philosopher's stone, which grants immortality to its owner. Harry and his friends, Hermione Granger and Ron Weasley, discover the plot and seek to prevent the theft of the stone, which is hidden in a protected chamber at Hogwarts.
Rowling personally insisted that the cast be kept British. Susie Figgis was appointed as casting director, working with both Columbus and Rowling in auditioning the lead roles of Harry, Ron and Hermione. Open casting calls were held for the main three roles, with only British children being considered. The principal auditions took place in three parts, with those auditioning having to read a page from Harry Potter and the Philosopher's Stone, then if called back, they had to improvise a scene of the students' arrival at Hogwarts, they were then given several pages from the script to read in front of Columbus. Scenes from Columbus's script for the 1985 film Young Sherlock Holmes were also used in auditions. On 11 July 2000 Figgis left production, complaining that Columbus did not consider any of the thousands of children they had auditioned "worthy". On 8 August 2000, the virtually unknown Daniel Radcliffe and the newcomers Emma Watson and Rupert Grint were selected from thousands of auditioning children to play the roles of Harry Potter, Hermione Granger and Ron Weasley, respectively.
- Daniel Radcliffe stars as Harry Potter, a seemingly normal child with a lightning shaped scar on his forehead and an ability to make strange things happen. His aunt and uncle, following the death of his parents, about whom he knows very little, raised him from the age of one. On his eleventh birthday, Harry discovers that he is a wizard and attends Hogwarts School of Witchcraft and Wizardry. Columbus had wanted Radcliffe for the role since he saw him in the BBC's production of David Copperfield, before the open casting sessions had taken place, but had been told by Figgis that Radcliffe's protective parents would not allow their son to take the part. Columbus explained that his persistence in giving Radcliffe the role was responsible for Figgis's resignation. Radcliffe was asked to audition in 2000, when Heyman and Kloves met him and his parents at a production of Stones in His Pockets in London. Heyman and Columbus successfully managed to convince Radcliffe's parents that their son would be protected from media intrusion, and they agreed to let him play Harry.Rowling approved of Radcliffe's casting, stating that "having seen [his] screen test I don't think Chris Columbus could have found a better Harry." Radcliffe was reportedly paid £1 million for the film, although he felt the fee was not "that important". William Moseley, who was later cast as Peter Pevensie in The Chronicles of Narnia series, also auditioned for the role.
- Rupert Grint plays Ron Weasley, a red-haired wizarding boy, the youngest boy of seven children from a disadvantaged family, who develops a long standing friendship with Harry. At thirteen years old, Grint was the oldest actor of the trio. He decided he would be perfect for the part "because [he has got] ginger hair," and was a fan of the series. Having seen a Newsround report about the open casting he sent in a video of himself rapping about how he wished to receive the part. His attempt was successful as the casting team asked for a meeting with him.
- Emma Watson plays Hermione Granger, an extremely intelligent witch who was "Muggle-born" who, despite initially irritating them, becomes friends with Harry and Ron after the pair save her from a troll. Impressed with her school play performances, Watson's Oxford theatre teacher passed her name on to the casting agents. Watson took her audition seriously, but "never really thought [she] had any chance of getting the role." The producers were impressed by Watson's self-confidence and she outperformed the thousands of other girls who had applied. Rowling was supportive of Watson from her first screen test.
- Richard Harris as Albus Dumbledore: The Headmaster of Hogwarts and one of the most famous and powerful wizards of all time. He decides that Harry should stay at his aunt and uncle following the death of his parents at the hands of Lord Voldemort. Harris initially rejected the role of Dumbledore, only to reverse his decision after his granddaughter stated she would never speak to him again if he did not take it.
- Robbie Coltrane as Rubeus Hagrid: A half-giant and the Groundskeeper at Hogwarts. He takes Harry to Privet Drive on a flying motorcycle, and then takes him from his aunt and uncle on his eleventh birthday, after which the two develop a strong bond. He has a fondness for magical creatures, in particular dragons. Coltrane was Rowling's first choice for the part. Coltrane, who was already a fan of the books, prepared for the role by talking with Rowling about Hagrid's past and future.
- Alan Rickman as Severus Snape: The Potions Master and head of Slytherin House at Hogwarts. He dislikes Harry due to a grudge he held with Harry's father. He was formerly a Death Eater but is trusted by Dumbledore. Tim Roth was interested in the role because his children were fans of the books, but ultimately a busy schedule meant he chose to film Planet of the Apes instead.
- Maggie Smith as Minerva McGonagall: The Deputy Headmistress, head of Gryffindor and Transfiguration teacher at Hogwarts. She accompanies Dumbledore to Number 4 Privet Drive when Harry is taken to his aunt and uncle and has the ability to transform into a tabby cat. Smith was Rowling's personal choice for the part.
- Tom Felton as Draco Malfoy: A wizard from a rich background. After Harry rejects his initial offer of "friendship", Draco develops an ever-lasting hatred of Harry and his friends. Along with Radcliffe, Felton was the only one of the main group of child actors to have previous on-screen acting experience.
- Ian Hart as Professor Quirrell: The slightly nervous Defence Against the Dark Arts teacher at Hogwarts. He wears a turban, which harbours the near dead form of Lord Voldemort underneath. David Thewlis auditioned for the part; he would later be cast as Remus Lupin in Harry Potter and the Prisoner of Azkaban.
- Richard Griffiths as Vernon Dursley: Harry's uncle who treats him poorly, only caring for his son Dudley. He does not wish Harry to find out about his identity, and burns every letter Hogwarts sends.
- Fiona Shaw as Petunia Dursley: Harry's aunt, who, like Vernon, treats him poorly.
- Harry Melling as Dudley Dursley: Harry's over-weight, bullying, and spoiled cousin.
- John Hurt as Mr Ollivander: The owner of Ollivander's, the finest wand producers in the wizarding world. Ollivander possesses the ability to find the perfect wand for any person who needs one, and claims to remember every wand that he has ever sold. He tells Harry that he received his scar from Lord Voldemort.
- Matthew Lewis as Neville Longbottom: A timid student who is a friend of Harry, Ron and Hermione. He is the frequent target of Malfoy and his gang.
- Warwick Davis as Filius Flitwick: A small wizard who is the Charms teacher and head of Ravenclaw at Hogwarts.
- John Cleese as Nearly Headless Nick: The ghost of Gryffindor house, his head is partially severed following a botched execution.
- Julie Walters as Molly Weasley: Ron's caring mother. She shows Harry how to get to Platform 9¾. Before Walters was cast, American actress Rosie O'Donnell held talks with Columbus about playing Mrs. Weasley.
- Richard Bremmer as Lord Voldemort: The darkest wizard of the age. He was defeated and nearly destroyed, when the killing curse he attempted to use on Harry rebounded and hit him. He was reduced to existing only as part of a host body and searches for the Philosopher's stone and a chance for immortality. Bremmer only plays Voldemort in the flashback scene. During the film's conclusion when he is revealed to Harry, Voldemort's voice and motion capture is provided by Ian Hart.
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